Ruthless siblings Roderick and Madeline Usher have built Fortunato Pharmaceuticals into an empire of wealth, privilege and power. But past secrets come to light when the heirs to the Usher dynasty start dying at the hands of a mysterious woman from their youth.

A stranger called Allan goes to the House of Usher. He is the sole friend of Roderick Usher, who lives in the eerie house with his sick wife Madeleine. When she dies, Roderick does not accept her death, and in the dark night, Madeleine returns.

In this animated version of Edgar Allan Poe's story, a traveller arrives at the Usher mansion to find that the sibling inhabitants are living under a mysterious family curse. The brother's senses have become painfully acute, while his sister has become nearly catatonic.