After high school slacker Ferris Bueller successfully fakes an illness in order to skip school for the day, he goes on a series of adventures throughout Chicago with his girlfriend Sloane and best friend Cameron, all the while trying to outwit his wily school principal and fed-up sister.

Top student Jane Ryan heads to Manhattan for a college-scholarship competition. Her rebellious twin Roxy Ryan goes along to crash a video shoot. But anything can happen - and does - in a romp involving a pursuing truant officer, a smuggler, hunkalicious guys and the girls' realization that when the chips are down, a sister can be the best friend of all.