When Li Xia and her best friend enroll into the arts specialized Qian Chuan secondary school, they meet the legendary Fu Xiao Si and Lu Zhi Ang. Together, the group of youths officially begin their beautiful high school life. After graduation, the friends part with everyone going their separate ways, but everyone continues to fight for their dreams. However, they're all gradually changing and thus become doubtful about the origin of their friendship. A span of ten years makes them realize that other than memories, nothing can be eternal, but they learnt to love and grow.

Three medical personnel from different backgrounds end up in the same aviation rescue team, thus starting a hot-blooded story about overcoming obstacles and saving lives.

The anime is set in the birthplace of the popular card game Rush Duel, Mutsuba-cho. Twins Yūhi and Yuamu run UTS (Uchūjin Trouble Sōdansho or Alien Trouble Consulting), a group that (supposedly) gets rid of troublesome aliens from distant sectors of the galaxy via Rush Duel battles. However, one day, they find an actual spaceship, and inside they find Yudias, an alien from the Belgar Cluster. Yudias has come to Earth to search for Rush Duel to hopefully lead him and his friends (who have been chased out of their star system) into a new future. However, Yudias himself knows nothing about Rush Duel. Yūhi then challenges Yudias to a duel.

Yeon-woo sees the world only in grey light by a neurological blindness. When he meets Yoo-han, it's like a meeting of destiny: Yeon-woo experiences a color rush, a phenomena which makes him suddenly see colours through intense experiences. Next to these strange experience and the question whether Yeon-woo and Yoo-han are destined lovers, there is also the mystery of a mother's disappearance to unfold.

A man dying of terminal illness receives an experimental body replacement surgery. He soon discovers that he has memories that are not his own along with superhuman powers. However, the dark history of the treatment becomes intertwined with his life as he has to survive and keep his loved ones safe.