Stuart Little: The Animated Series is an American animated television series, loosely based on the E. B. White children's book Stuart Little and more based on the live action movie adaptations. It was produced by Red Wagon Productions and Sony Pictures Television for the HBO Family digital cable television channel, and aired for just one 13-episode season in 2003.

The adventures of a heroic and debonair stalwart mouse named Stuart Little with human qualities, who faces some comic misadventures while living with a human family as their child.

Stuart, an adorable white mouse, still lives happily with his adoptive family, the Littles, on the east side of Manhattan's Central Park. More crazy mouse adventures are in store as Stuart, his human brother, George, and their mischievous cat, Snowbell, set out to rescue a friend.

With school out for the summer, The Littles are vacationing in a cabin by the lake, and Stuart is so excited he could burst! But when Snowbell the cat is captured by a mean-spirited creature known simply as the Beast, it's up to Stuart and a skunk named Reeko to rescue him and a few other friends.