Ritchie Donovan is a professional thief whose luck has just run out. The only survivor from a heist that goes terribly wrong, Ritchie is forced to take the rap and is sent to Russia to steal a priceless antique cross locked in a safe on the penthouse floor of a Moscow skyscraper.

With the help of his girlfriend Cathy and Dr. Fong, a psychiatrist, ambitious journalist Johnny Barrett poses as a madman in order to be admitted to a mental institution where a bloody murder has been committed.

Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.