Florence, 1631. The black plague rages, the streets are deserted, healthy citizens are confined. Alvise, a plague doctor, discreetly paces the city in search of infected bodies to conduct his experiments, in the hope of finding a cure. One day, during an autopsy, a strange creature springs from one of the corpses...

The Black Death, a pandemic disease that ravaged in the 1300s, caused a never-before-seen human catastrophe of frightening magnitude. Over the course of three terrible years, more than a third of Europe's population was wiped out.

A lord returns to his manor with his new wife, to hear rumours that he had already secretly returned and had committed several murders. Has he lost his mind, or is something dark afoot ?