"Mariana & Scarlett" centers on two sisters with dreams of fashion success. Their close bond is tested when they fall for the same man, Roberto. Set in the glamorous fashion world, the telenovela explores the complexity of sisterhood, love, and ambition, leading to a dramatic love triangle filled with betrayal.

30-year-old single Mary Richards moves to Minneapolis to start a new life after a romantic break-up. There she reacquaints with Phyllis who rents her a room, and meets her upstairs neighbor and new best friend Rhoda. Mary unexpectedly lands a job as associate producer at the TV station WJM, where she works alongside her bristly boss, Lou; the comical newswriter, Murray; and the newscast's often-incompetent anchor, Ted.