A joyous family reunion becomes a hilarious nightmare as Madea and the crew travel to backwoods Georgia, where they find themselves unexpectedly planning a funeral that might unveil unpleasant family secrets.

Southern matriarch Madea has a lot on her plate. Her nieces, Vanessa and Lisa, have relationship troubles - Vanessa moves into Madea's house with her 2 young children and Lisa is engaged to a controlling man that her mother set her up with. In addition, Madea has just been court-ordered to become the guardian of Nikki, a rebellious runaway teenager. Madea must keep the peace and her family together while simultaneously planning her clan's reunion.

When Shirley, Madea's niece, receives distressing news about her health, the only thing she wants is her family gathered around her. However, Shirley's three adult children are too preoccupied with their own troubled lives to pay attention to their mother. It is up to Madea, with the help of rowdy Aunt Bam, to bring the clan together and help Shirley deal with her crisis.

The fireworks begin when Madea’s family gathers for her granddaughter’s wedding. As usual, Madea rules the roost, as she and her neighbor, the wacky Mr. Brown, deliver nonstop laughs. Live, love, rejoice...it’s Madea’s Family Reunion!

Shirley has important news for her family, but she has five grown children with different lifestyles and finds it difficult to get them and the kids all together. So in steps Madea, the Matriarch General, to put the family's life in perspective with a hilarious twist on financial difficulties, drugs and, most important, family secrets. The next generation has a lot to learn. In her own way, Madea expresses how deliverance won't change you to be someone else, but will allow you to be who you really are.