A portrait of the bloody dynasty that spawned a pope, Alexander VI, as well as the role model for Machiavelli's “The Prince,” his son Cesare Borgia, and a legend of femme duplicity, daughter Lucrezia Borgia.

Set in 15th century Italy at the height of the Renaissance, The Borgias chronicles the corrupt rise of patriarch Rodrigo Borgia to the papacy, where he proceeds to commit every sin in the book to amass and retain power, influence and enormous wealth for himself and his family.

The tiny independent duchy of Ferrara is located between Casare Borgia's Rome and Venice, and Borgia has plans to conquer Venice via Ferrara. He murders his sister's husband and makes it appear that Alfonso D'Este of Ferrara was behind the killing. To avenge herself against Ferrara and D'Este, Lucretia Borgia marries D'Este and intends to poison him. But...she falls in love with him.

In 1500, Duke Cesare Borgia hopes to marry his sister to the heir apparent of Ferrara, which impedes his conquest of central Italy. On this delicate mission he sends Andrea Orsini, his sister's lover and nearly as unscrupulous as himself. En route, Orsini meets Camilla Verano, wife of the count of Citta' del Monte, and sentiment threatens to turn him against his deadly master, whom no one betrays twice...