Yuki's family is nearly wiped out before she is born due to the machinations of a band of criminals. These criminals kidnap and brutalize her mother but leave her alive. Later her mother ends up in prison with only revenge to keep her alive. She creates an instrument for this revenge by purposefully getting pregnant. Yuki never knows the love of a family but only killing and revenge.

Lady Snowblood is caught by the police and sentenced to death for her crimes. As she is sent to the gallows she is rescued by the secret police who offer her a deal to assassinate some revolutionaries.

In this interview, conducted in 2015, prolific author Kazuo Koike talks about his original LADY SNOWBLOOD manga.