Seymour works in a skid row florist shop and is in love with his beautiful co-worker, Audrey. He creates a new plant that not only talks but cannot survive without human flesh and blood.

Seymour Krelborn is a nerdy orphan working at Mushnik's, a flower shop in urban Skid Row. He harbors a crush on fellow co-worker Audrey Fulquard, and is berated by Mr. Mushnik daily. One day Seymour finds a very mysterious unidentified plant which he calls Audrey II. The plant seems to have a craving for blood and soon begins to sing for his supper.

Disguised aliens set up a pet shop in a dusty Arizona town, hoping to lure local children with their adorable extraterrestrial critters.