After his brother's death, Larry Talbot returns home to his father and the family estate. Events soon take a turn for the worse when Larry is bitten by a werewolf.

Emile Pulska is visiting his old friend Abe Stillman. During the visit they are attacked and Emile is struck senseless. When he wakes up he is told that Abe is dead, dead by natural causes, the doctors tell him. When Emile insists that they were attacked, his relatives try to give him psychiatric help. Emile decides to try to find the killers himself, but someone is watching his every step...

As Alvin struggles with nightmares involving werewolves, the school play of Jekyll & Hyde is in jeopardy when the lead, Alvin, is suspended. In an attempt to boost his confidence, the principal suggests Theodore, who's suddenly going through some canine changes.

Grave robbers open the grave of the wolf man and awaken him. He doesn't like the idea of being immortal and killing people when the moon is full so tries to find Dr. Frankenstein, in the hopes that the doctor can cure him. Dr. Frankenstein has died; however, his monster is found.