Charley Partanna is a hitman who works for the Prizzis, one of the richest crime families in the US. When he sees Irene Walker, it's love at first sight. But he soon finds that she, too, is a killer for hire. Charley can overlook his suspicions, but he can't turn off his heart. And the couple must remember that even if they love each other, the Prizzis love only money.

A charming thief and a band of unlikely adventurers undertake an epic heist to retrieve a lost relic, but things go dangerously awry when they run afoul of the wrong people.