1945: The red army stands at the gates of Berlin. In their desperation the Nazis turn to the most obscure Scientists. Through cruel experiments a new secret Weapon has been created - unstoppable and alive. A Russian attack destroys the lab, but the weapon - buried underneath the ruins - is immortal. Lost in time, it lurks in the darkness, only to return again. 2012: Punk-Rock legend Spike Jones leads a group of friends into the ruins of the old Nazi Lab. The complex shall be cleaned up for the reunion concert of his band. Believing they would help a poor soul, they free the beast from its prison. But the creature of the Nazis does not know about thankfulness. Again the smell of blood fills the old laboratories and screams of terror echo through the darkness. As now, the Werewolf starts his war against humanity.

One day, a son of a king went for a ride in the woods. He fell asleep and didn’t notice he was deep in the forest, where the iron wolf lives. The angry roar and the gnashing of steel jaws awakened him, and he broke into a run to save himself from the dreadful monster.

Ogami Itto is a master swordsman who holds a position of high power in the Tokugawa Shogunate. Highly trusted by the Shogun, he serves as the official decapitator, assisting lords and samurai who have been ordered by the Shogun to commit seppuku. One day, Itto’s wife and members of his household are brutally murdered by a clan seeking to avenge their lord’s execution, which had been carried out by Itto. In the wake of the attack, two items are left in Itto’s home: his unhurt infant son, Daigoro, and a symbol meant to signify Itto’s betrayal of the Shogun. Disgraced by the false symbol, Itto is labeled a traitor and forced to forfeit his position. He becomes a ronin, wandering the country with his son, searching for the men who killed his wife, seeking to clear his name and avenge her death.