A reality in which the definitive cure for HIV-AIDS has been found. The government, through the media, makes the announcement official and with it begins protocolization campaigns for HIV-AIDS immunity. But what about people who are already infected?

Mexico City, 1960. Aurelia lives happily with her family. Just before the birth of her third daughter, her husband dies in an accident. Years later, Leonor, the oldest daughter, has quit her studies to help her mother support the household. Beatriz, immersed in her music, lets life slip her by like a strange melody. Adolescent Nadia has only one interest in life: to seek new experiences. Aurelia starts to lose her sensibility to pain, and the family relationships become so alienated that they begin to disintegrate like the house they live in.

During a pandemic lockdown, Nico, a young man with rare immunity, must overcome martial law, murderous vigilantes and a powerful family to reunite with his love, Sara.