A gang of thugs devise a cruel hoax that goes horribly wrong as Melvin, a nerdy emaciated janitor at the local health club, is cast through a third story window into a vat of hazardous toxic waste.

A horrific explosion creates a dimensional portal between Tromaville and its dimensional mirror image, Amortville. While the Toxie is trapped in the mirror dimension, Tromaville comes under the control of his evil doppelganger, the Noxious Offender.

Melvin Junko was a nerdy weakling until he fell into a vat of toxic waste, turning him into the first ever superhuman creature from New Jersey. This time, he takes on Tokyo.

Desperate to raise money for the experimental surgery that could restore his blind fiancee's eyesight, Toxie accepts a lucrative job with the evil multinational conglomerate Apocalypse Inc.