During the Italian Renaissance, Pope Julius II contracts the influential artist Michelangelo to sculpt 40 statues for his tomb. When the pope changes his mind and asks the sculptor to paint a mural in the Sistine Chapel, Michelangelo doubts his painting skills and abandons the project. Divine inspiration returns Michelangelo to the mural, but his artistic vision clashes with the pope's demanding personality and threatens the success of the historic painting.

Young Matt Matthews, an Ozark Mountains moonshiner, hates the father he has never seen, who apparently deserted Matt's mother and left her to die. His obsession contributes to the hatred rampant in the mountains. However, the arrival of a stranger, Daniel Howitt, begins to positively affect the mountain people, who learn to shed their hatred under his gentle influence.