On his uncle's death Sir Henry Baskerville returns from Canada to take charge of his ancestral hall on the desolate moors of Devonshire, and finds that Sherlock Holmes is there to investigate the local belief that his uncle was killed by a monster hound that has roamed the moors since 1650, and is likely to strike again at Sir Henry.

Sherlock Holmes and Dr. Watson are called in to unravel a mysterious curse that has plagued the Baskerville family for generations. When Sir Charles Baskerville is found dead, his heir, Sir Henry, begs Holmes to save him from the terrifying supernatural hound that has brought fear and death to his household.