Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.

Hannah and Amber Baker are trapped in a dark Southern underworld of violence, drugs and bikers. Both live in fear of their "Uncle Frank" Stinson, the ruthless leader of a crime organization.

A deadly manhunt takes three people through the sordid streets of the Philadelphia underworld, in search of killers and the truth, where every clue brings new questions.