After bouncing back from leukemia, 10-year-old Mike is ready to leave the hospital, but his mother never arrives to take him home.

Three teenagers appear to have a lot of fun on the children's oncology department on the fourth floor of a large hospital. Nick and Iwan both lost a leg as a result of bone cancer. For their friend Olivier, an amputation may be the next phase. The fourth of the bunch, Pepijn, is so ill and weak that he often stays in his room. Friendship and a deep desire to live keeps the guys mentally balanced. Their friendship changes when Gina arrives. Sickos is a humorous drama that deals with adolescence and chemotherapy.