Dafne has recently lost her mother – and Luigi his wife – in an accident. But whilst this 30-year-old, who was born with Down’s syndrome, is still managing to master her life with verve after the terrible disaster, her father sinks into a depression. It will take all the energy Dafne can muster to help him get back on his feet. Fortunately, headstrong Dafne happens to have a lot of it up her sleeve.

Dafne and her friends are a bunch of thirty-somethings living dissatisfied lives. Frustrated in love and sex, they work in lousy jobs, trying to find themselves, and some love, in Madrid.