What To Do In Case of Fire? tells the humorous and touching story of six former creative anarchists who lived as house squatters in Berlin during its heyday in the 80s when Berlin was still an island in the middle of the former eastern Germany. At the end of the 80s they went their separate ways with the exception of Tim and Hotte, who have remained true to their ideals and continue to fight the issues they did as a group. In 2000, with Berlin as Germany's new capital, an event happens forcing the group out of existential reason to reunite and, ultimately, come to grips with the reason they separated 12 years ago.

Nicolás, a photographer, has suffered epilepsy since childhood and he is forced to take care of himself and sacrifice a lot, though he lives a normal life. On the other hand, Isabel is a woman who, apparently, has her whole life figured out although her mother is ill and she has no choice but to try to save her. Isabel and Nicolás fall in love in spite of themselves, their demons, their ghosts, and their weaknesses. Suddenly engaged in a relationship none of them would have even dared to imagine, they experience the love, passion, insecurity, fear, and allergy to commitment typical in people who are drifting away.

Five different criminals face imminent death after botching a job quite badly.