In the Forest of Okoya, Koko is a feral child who has been raised as a Pokémon by the Mythical Pokémon Zarude. Koko has grown up never doubting that he is a Pokémon even though he can't really use any sort of moves. Ash Ketchum and Pikachu meet Koko and help him protect the Great Tree from the crooked scientist Dr. Zed.

The film chronicles George's adventures as he befriends Kayla, a baby elephant, at a magic circus show and helps her travel across the country to be reunited with her family.Accompanied by his friend, the Man with the Yellow Hat, George travels by foot, train, and truck to reach Kayla's brother and sister in California, only to be accused of elephant-napping and brought all the way back to New York.