Charlie Chan, with son Jimmy on a week's pass from the Army, takes up a request for help at a castle-home, miles from anywhere in the American desert south-west and inhabited by an eccentric, reclusive historian and his wife, a descendant of Lucrezia Borgia. Once there, he finds the request's legitimacy denied by all who are present, but still necessary as one houseguest has already been murdered, the other guests are at each other's throat, and the Borgia-related chatelain is suspected...

A treasury agent on the trail of counterfeit money confides to fellow ocean liner passenger, Charlie Chan, that there have been two attempts on his life.

Soon after a Chinese princess comes to the US to buy planes for her people, she is murdered by a poison dart fired by an air rifle.

Movie star Shelah Fane is seeing wealthy Alan Jaynes while filming in Honolulu, Hawaii, but won't marry him without consulting famed psychic Tarneverro first. Enter inspector Charlie Chan of the Honolulu Police, investigating the unsolved murder, three years earlier, of a Hollywood actor.

When Charlie's old friend from Scotland Yard is murdered when they attend a police convention in New York, Chan picks up the case he was working on.

Sir George hires Hillary Gatt to find out more about Eric who wants to marry Lois. Gatt is murdered and the couple, married, run off to India. Old friend John Beetham sympathizes with the bride who sees that her hubby is a liar and drunk.

In order to learn the location of a fabled Aztec treasure, a professor kidnaps his colleague, the only man able to read the ancient Aztec script that is supposed to reveal the location of the treasure. Charlie Chan and his #1 and #2 sons journey to the jungles of Mexico to find the victim and bring the kidnapper and his gang to justice.

When the elderly woman sponsoring a treasure hunt is murdered on board her docked ship, Charlie Chan must deal with a treasure map in four pieces, the ghost of a hanged pirate, a talking parrot, a recalcitrant sea captain and several suspicious passengers - and a second murder.

A gold mine in Arizona, that was formerly losing a lot of money, suddenly turns into a veritable money-making machine. However, the owner, instead of being happy about his now profitable business, insists to Charlie that something is fishy and that someone is out to murder him. Charlie and his "crew" travel to the mine, pretending to be tourists staying at a nearby dude ranch so as not to arouse suspicion, and discover that the owner may well be right--it looks like the mine is being used as a cover for criminal activities, and that someone is indeed out to murder him.

All the passengers on an airplane headed for San Francisco are drugged, and when they wake up, it is discovered that a quarter-million dollars is missing. Charlie Chan--and, of course, his #1 son--must discover the identity of the person who doped the passengers and stole the money.

Someone is attempting to steal radium stored in a bank. Death by cobra venom connects a number of murders. Charlie Chan investigates.

Celebrated as supersleuth, Mr. Moto comes out fighting when a brutal boxing match turns into cold-blooded murder! Assisted by detective-in-training Lee Chan, Moto sets out to track down the killer based on a single ominous clue: a poisoned boxing glove! But when Moto's hunch points to a corrupt gambling syndicate, he's forced to wager his very life to unmask the culprit—or go down for the count...permanently!

Detective Charlie Chan springs into action when top officials of a New Orleans chemical company begin dropping like flies.

Charlie attempts to solve a triple murder in which a dead man's finger prints show up at all three murder sites, and all three victims were connected with the conviction and execution of an evidently innocent man.