When a virus leaks from a top-secret facility, turning all resident researchers into ravenous zombies and their lab animals into mutated hounds from hell, the government sends in an elite military task force to contain the outbreak.

As the city is locked down under quarantine, Alice finds out that the people that died from the previous incident at the Umbrella Corporation have turned into zombies. She then joins a small band of elite soldiers, who are enlisted to rescue the missing daughter of the creator of the mutating T-virus. Once lack of luck and resources happen, they begin to wage an exhilarating battle to survive and escape before the Umbrella Corporation erases its experiment from the face of the earth.

BSAA Chris Redfield enlists the help of government agent Leon S. Kennedy and Professor Rebecca Chambers from Alexander Institute of Biotechnology to stop a death merchant with a vengeance from spreading a deadly virus in New York.

Leon S. Kennedy and Claire Redfield must battle a rogue warrior seeking revenge after unleashing the deadly G-Virus, whilst a mutated monster goes on a rampage.

Years after the Racoon City catastrophe, survivors travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against hordes of zombies and the evil Umbrella Corp.

It has been over one year since the start of the outbreak. Our society has collapsed and the world has descended into chaos. Elvis and Tweeter are two of the last people left alive, and band together to flee the United States for a remote island somewhere in the Caribbean. On the island, they find a new community struggling to hold out against an army of corpses. They can join this band of survivors-- but only if they can do what must be done for the good of the group.

A headstrong animal-rights activist group plans a raid on a bio-tech company to stop the cruelty. They discover the true nature of the experiments that are really taking place. As they break into a biotech lab only to have their idealism crushed by the terrifying things they find inside. But when a genetically mutated human with a taste for human flesh gets released, they all struggle to survive!

In a world ravaged by a virus infection, turning its victims into the Undead, Alice continues on her journey to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation reaches new heights, but Alice gets some unexpected help from an old friend. A new lead that promises a safe haven from the Undead takes them to Los Angeles, but when they arrive the city is overrun by thousands of Undead - and Alice and her comrades are about to step into a deadly trap.

The violent Kluduthu, kidnap Aurora and take her to their desert home planet because she holds a secret power which could wipe out all of humanity. She is able to escape, only to find herself in the middle of a war which has been going on for millions of years.