Florence. Roberto Perzi returning home, after work finds his mother, Olga in the ground, headless. Amber Perzi eyewitness of the murder is completely in shock. The commissioner and the inspector, Marco Tagliaferri and Fabrizio Sartana deal with a series of heinous murders, with the murderer always one step ahead of the police.

After FBI agent Frank Lacrosse believes his son was kidnapped by a notorious serial killer, he travels to Amarillo, Texas, where he believes the murderer is in hiding. Although officially taken off the case because of its personal significance to him, Frank continues to pursue the killer, causing concern for local sheriff Buck Olmstead. When another victim pops up at a nearby car garage, Frank knows that he is as close as he'll ever be to tracking down the elusive killer.

An Alaska State Trooper partners with a young woman who escaped the clutches of serial killer Robert Hansen to bring the murderer to justice. Based on actual events.

Henry likes to kill people, in different ways each time. Henry shares an apartment with Otis. When Otis' sister comes to stay, we see both sides of Henry: "the guy next door" and the serial killer.