A giant alligator goes head to head with a giant Anaconda. The town sheriff must find a way to destroy the two monsters before they kill the whole town.

In the most remote areas of the Amazon rainforest, a writer and his anthropologist friend find communities that have resisted change for centuries.

Join barefoot scientist Jesús Rivas in the murky marshes of Venezuela on his quest to understand these huge, fearsome reptiles. Up to 30 feet long, weighing many times more than the scientists studying them, anacondas are difficult subjects at best, but the National Geographic team captures brilliant footage of them swimming, resting, mating, and hunting prey.

Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of human corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device they have.

The blood orchid - a rare flower that could hold the secret of eternal life and be worth a fortune to the company that finds it first. Led by a pharmaceutical research team, a scientific expedition sets out to go and explore deep into the jungles of Borneo to locate and bring back samples of the legendary plant. Battling through rainstorms to make their way upriver, the group encounters poisonous insects and a ferocious crocodile, only to discover they're being stalked by an even greater danger: a gathering of giant anacondas. Heat-sensing, fifty-foot-long flesh eaters that will go after anyone that crosses in their path.

A genetically created Anaconda, cut in half, regenerates itself into two new aggressive giant snakes, due to the Blood Orchid.

Anaconda - the mere mention of its name brings images of an awesome and terrifying killer snake! For Dr. Jesus Rivas and his wife, Dr Sarah Corey, anacondas represent a challenge as they try to unravel the mysteries surrounding these massive reptiles. Like most snakes, anacondas have suffered greatly from exaggeration and scary folklore. Pound for pound, the South American anaconda is the world’s largest snake. But its reputation as a killer is wrapped in myth and legend.