Opposite Lives tells the story of Miguel (Leo Rosa), a young rich man of a traditional family, and Joana (Maytê Piragibe), a student and tourist guide who lives in a slum. Although dating an elegant and rich fashion designer, Erínia (Lavínia Vlasak), Miguel and Joana fall in love for each other and they decide to get married.

Eva Lemos lives a stable and seemingly happy life, until Marco, her husband, disappears suddenly after knowing that she is pregnant. Marco steals all her money, leaving her homeless and without a job, while Eva learns that Marco was only with her out of interest and lives a double life with Maria. Hatred and revolt take Eva into a journey that transforms her deeply... and not for the better.