Best Friends follows the life of a group of friends at their high school ‘Spangalis College’. Inside and outside of school exciting and challenging experiences take place. Growing up is never easy; every character has its own, unique story of love, friendship, loneliness, sorrow, discovery. There is drama and joy in school, family, teachers, parents, divorce, bullying, and always dreams for the future.

Teacher Jochem sticks to the plan he has drawn up for the week-long study trip - in teams, the students will complete various assignments, the highlight of which will be a survival drop at the end of the week. Jochem tries to motivate the students, but has a hard time of it. Their tangled web of contradictory interests is not good for harmonious cooperation. Jochem has been over-optimistic in this respect and very soon the students' own agendas are revealed.

News that the school is supposed to suddenly close causes great agitation among the students. They decide to take direct action by occupying their school... The siege commands hard-action from the friends to protect their school and identities. Will they convince the board to keep the school open?