A single-camera half-hour comedy based on what Maria Bamford has accepted to be "her life." It's the sometimes surreal story of a woman who loses — and then finds — her s**t.

Donna Costanza is married to a New Jersey mafia boss. During their 10 year wedding anniversary party he is shot and killed. His dying words to her are "Giarratana from Palermo". Costanza takes a trip to Palermo in order to avenge the death of her husband. Her target is Don Giarratana, a dangerous and influential Italian politician.