Imagine a world with no adults, no strict rules, nothing to do but explore, learn, and most importantly, have fun. A rural world full of laughter, friendship, and games. A world in which the inhabitants seize the day, and each moment is received as a gift. Kukuli, a hyperactive monkey, and his two best friends, Tinky and Minky, are living it up in this dreamlike, magical realm.

Kukuli, a young llama herder, leaves her grandparents in the countryside of Cusco to attend the Feast of Mamacha Carmen in the town of Paucartambo.

Inventor Flint Lockwood creates a machine that makes clouds rain food, enabling the down-and-out citizens of Chewandswallow to feed themselves. But when the falling food reaches gargantuan proportions, Flint must scramble to avert disaster. Can he regain control of the machine and put an end to the wild weather before the town is destroyed?

After the disastrous food storm in the first film, Flint and his friends are forced to leave the town. Flint accepts the invitation from his idol Chester V to join The Live Corp Company, which has been tasked to clean the island, and where the best inventors in the world create technologies for the betterment of mankind. When Flint discovers that his machine still operates and now creates mutant food beasts like living pickles, hungry tacodiles, shrimpanzees and apple pie-thons, he and his friends must return to save the world.