A rich businessman is fed up with work, family, society, and goes with his accountant to Africa, in search of his brother-in-law who had vanished there in mysterious circumstances. They will find him alright - as a tribal chief, surrounded with lots of topless, shapely wives. They are going to return to civilisation, but will their friend come with them?

The plot chronicles the exploits of Michael, a teenager who is using marijuana and stealing his father's beer. His younger sister, Corey, is worried about him because he started acting differently. When her piggy bank goes missing, her cartoon tie-in toys come to life to help her find it. After discovering it in Michael's room along with his stash of drugs, the various cartoon characters proceed to work together and take him on a fantasy journey to teach him the risks and consequences a life of drug-use can bring and save the world.

Cartoon All-Stars to the Rescue is an American animated drug prevention television special starring many of the popular cartoon characters from American weekday, Sunday morning and Saturday morning television at the time of this film's release. Financed by McDonald's and Ronald McDonald Children's Charities, the special was originally simulcast on April 21, 1990 on all four major American television networks: ABC, NBC, FOX and CBS, and most independent stations, as well as various cable networks. McDonald's also distributed a VHS home video edition of the special, produced by Buena Vista Home Video, which opened with an introduction from President George H. W. Bush, and First Lady Barbara Bush. The show was produced by the Academy of Television Arts & Sciences Foundation and Southern Star Productions, and was animated overseas by Wang Film Productions Co., Ltd.. The musical number "Wonderful Ways to Say No" was written by Howard Ashman and Alan Menken, who also wrote the songs for The Little Mermaid, Beauty and the Beast and Aladdin. The plot chronicles the exploits of Michael, a teenager who is using marijuana and stealing his father's beer. His younger sister, Corey, is worried about him because he started acting differently. When her piggy bank goes missing, her cartoon tie-in toys come to life to help her find it. After discovering it in Michael's room along with his stash of drugs, the various cartoon characters proceed to work together and take him on a fantasy journey to teach him the risks and consequences a life of drug-use can bring and save the world.