Cheyenne is an American western television series of 108 black-and-white episodes broadcast on ABC from 1955 to 1963. The show was the first hour-long western, and in fact the first hour-long dramatic series of any kind, with continuing characters, to last more than one season. It was also the first series to be made by a major Hollywood film studio which did not derive from its established film properties, and the first of a long chain of Warner Brothers original series produced by William T. Orr.

Slick gambler James Wylie (Dennis Morgan) is apprehended by the law and given the option to forgo a prison sentence if he poses as a bandit. His mission is to uncover the identity of the Poet, a notorious outlaw who has been holding up bank-owned stagecoaches and leaving verses at the crime scenes to taunt the authorities. James finds time to woo the Poet's lovely wife, Ann (Jane Wyman), who initially cold-shoulders him. But, as a romance develops, they partner up to find the robber.

After she's caught sleeping with the ranch hand, Cheyenne (Bobbie Phillips) shoots her good-for-nothing husband and takes off with his money. Her hubbie doesn't want to part with her, however, and now the feisty Cheyenne has not one, but two bounty hunters on her tail. Jeremiah (Gary Hudson) may think that he's the best bounty hunter on the frontier, but Haddox (M.C. Hammer) and his evil dwarf Razor (Bobby Bell) have their minds set on bringing Cheyenne in, even if they have to take out Jeremiah just to get to her.

Cal Roberts can ride anything with four legs. He enters the contests held at big rodeo. He wins all honors and meets a girl who races horses to help her father clear pressing debts. Complications follow, but Cal wins the girl.

Just released from prison six months ago, Cheyenne is cleaning ferries while dreaming of fleeing to the Amazon. Lola is a stunning, selfish Parisian without scruples who appears in the north of France to move in with her lover. When Lola murders her lover's wife, Cheyenne, an involuntary witness, knows she will be charged with the murder because of her criminal record. She is obliged to seek help from the local crime boss to get rid of the body. A favor that will drag the two women into a dangerous game of duplicity, all while making a fortune behind everyone's back.