Taking place mainly in Bogotá, Colombia, Betty La Fea is essentially a Cinderella comedy about the rise of poor, ugly 'Betty' Pinzón and the fall of rich, handsome Armando Mendoza. Armando is a very incompetent playboy with a scheme to turn a huge profit as the new President of Eco Moda, a famous clothing manufacturing company, but his scheme is doomed because of his faulty mathematics. Because Betty, his secretary (and economics wizard), is in love with him, she helps Armando deceive the Board of Directors as he loses money and brings the company to ruin. Betty, la Fea is arguably the most successful telenovela of all time and one of the most popular television shows in the world. It is the first telenovela to have been remade worldwide and has been regarded as bringing the telenovela to new levels of success.

Betty is a young Latina in New York who, rejected in multiple jobs, accepts one below her qualifications in the fashion industry. Amid the glamor and business, the war between the pretty and the ugly, Betty grows and faces the biggest challenge of her life: love.

While an empowered and wiser Betty works hard on rebuilding her relationship with her teenage daughter Mila, her relationship with Armando begins to deteriorate, making her question if she made the right decision 20 years ago.

Betty Suarez is smart, tough and tenacious, but also sensitive and loving. She hopes these skills will help her to get a job within the Meade Publishing Corporation. The fact that she isn’t traditionally attractive initially keeps her from getting hired by fashion bible, Mode. The magazine, however, is in flux, with power-hungry executives vying for dominance. Hoping to control the situation, the publisher gives his inexperienced son, Daniel, the position of Editor-in-Chief. He hires Betty as Daniel’s assistant after catching him in a compromising position with his secretary on his first day on the job. After a tough start, in which Daniel tries to force Betty into quitting by treating her terribly, he realizes her worth and the two pair up to be an effective team.

A lackadaisical handyman and aspiring novelist tries to support his younger girlfriend as she slowly succumbs to madness.